Supporting your PCOS journey
Polycystic Ovary Syndrome (PCOS) is a common hormonal disorder that affects many women. It can have a significant impact on fertility, making it difficult for women with PCOS to conceive. The good news is that there are non-prescription options available to help manage PCOS and its symptoms. One option is myo-inositol, a naturally occurring sugar created by the body, that has been shown to improve hormone balance and egg quality when taken as a supplement in women with PCOS. In this article, let’s explore the benefits of myo-inositol for PCOS, and compare the dosing of myo-inositol powder and Inofolic softgel capsules.
Understanding myo-inositol and its benefits for PCOS
Myo-inositol is a naturally occurring substance that is found in human tissues, including in the ovaries at a high concentration. It plays a crucial role in many cellular functions, including insulin signaling and hormone regulation. For women with PCOS, myo-inositol can have several benefits. At 4,000 mg, myo-inositol has been clinically proven to help improve insulin sensitivity, which is often impaired in women with PCOS. By enhancing insulin sensitivity, myo-inositol helps to regulate blood sugar levels and reduce the production of androgens, the male hormones that are often elevated in women with PCOS. This, in turn, can help to restore ovulation and improve fertility.
How myo-inositol supports fertility and hormone balance
One of the key benefits of myo-inositol is its ability to support fertility and hormone balance in women with PCOS. Research has shown that myo-inositol supplementation can help to restore regular ovulation and improve egg quality. This is especially important for women trying to conceive, as irregular ovulation and poor egg quality are common issues in PCOS. In addition, myo-inositol can help to regulate hormone levels, particularly insulin and androgens. By improving insulin sensitivity and reducing androgen production, myo-inositol helps to rebalance hormones and improve overall fertility. (more information about myoinositol and fertility from a naturopath’s perspective click here.)
The difference between myo-inositol powder and soft-gel capsules
While both formats contain the same active ingredient, there are some differences in their formulation and delivery. Myo-inositol powder form can be mixed with water or other liquids and drank twice daily. It was the initial form of myoinositol available and may be preferred by those who do not like taking pills or capsules.
On the other hand, Inofolic softgel capsules offers a convenient and precise way to take myo-inositol. The soft-gel capsules ensure accurate dosing, and some may find them easier to take if they are always on the go. Researchers have created the softgel capsule as an evolution from the powder format.
Inofolic Soft-Gel Capsules and their unique dosing
Inofolic softgel capsules are an innovative form of myo-inositol. Myo-inositol in powder form might not be absorbed as effectively by the body due to certain factors.2 This means a greater amount of powder is needed to get the desired results, which could cause more side effects and make it harder for people to take it regularly. When developing supplements, how well the body can absorb them is important. This is called bioavailability. It shows how much and how quickly a substance gets into your bloodstream when you take it, especially when taken orally. Softgel capsules provide uniform, faster and enhanced absorption compared to other oral forms. 2
To address this, scientists developed a new soft gelatin capsule form of myo-inositol combined with folic acid, called Inofolic®.
Softgel capsules are not just any type of capsule! Each Inofolic softgel capsule consists of a thick liquid containing 600 mg of myoinositol with 200 mcg of folic acid enveloped by an airtight sealed shell. In a bioavailability study, a 600 mg myo-inositol softgel capsule was tested against 2,000 mg myo-inositol powder to study the body’s absorption.1 The myo-inositol in the softgel capsule. showed better absorption compared to the powder. When they examined two 600 mg myo-inositol softgel capsules (1,200 mg total) against 4,000 mg myo-inositol powder, the same bioavailability was shown. This means despite containing approximately three times less myo-inositol, the soft-gel capsule achieved the same blood levels as the powder.
Inofolic softgel capsules can be taken as 2 capsules once daily; or 1 capsule twice daily (preferably 12 hours apart) separated from meals.
Canadian researchers weigh-in on softgel capsule technology
Researchers at the University of Waterloo describe the advantages of softgel capsule technology2, which include:
- Consumer preferences: Softgel capsules can conceal unpleasant taste and odour of medication. Compared to tablets, softgel capsules can also be easier to swallow when taken with water, because they are self-lubricating.
- Technical advantages: The manufacturing requirements and product stability with softgel capsules help ensure precise and consistent dosing.
- Protection from contamination: The gelatin shell seals tightly, keeping the contents inside safe from air and pollution.
- Bioavailability: Softgel capsules help poorly soluble medications and powders dissolve more easily, be absorbed better in the stomach and intestine.
Other considerations with softgel capsules include higher costs, as this advanced technology means that softgel capsule products are more expensive to produce. Another consideration is dietary restrictions, as softgel capsules are often made with animal biproducts.
Myo-inositol powder vs. Inofolic Soft-Gel Capsules: Which is right for you?
Choosing between myo-inositol powder and Inofolic softgel capsules can depend on a variety of factors. Personal preferences and lifestyle are important considerations. If you prefer taking a supplement in a powder format and mixing it with water or another drink, and are consistent with measuring your own dosing, myo-inositol powder may be a suitable choice for you. However, if convenience and accuracy are important, Inofolic softgel capsules offer an alternative way to take myo-inositol along with folic acid. The soft-gel capsules provide a precise dosage and can easily be incorporated into your daily routine, making them a popular choice for busy individuals.
Tips for taking Inofolic softgel capsules
To maximize the benefits of Inofolic softgel capsules, it is important to:
- Take Inofolic as directed and make sure you read and follow the label.
- Take Inofolic consistently and at the recommended dosage of 2 capsules once daily; or 1 capsule twice daily (preferably 12 hours apart) separated from meals.
- Be prepared to take Inofolic for an extended period. Studies show that after 4 months of myoinositol use, 70% of patients experienced a restored menstrual cycle. For reduced PCOS skin related symptoms, such as acne and excess hair growth (hirsutism), patients may need up to 6 months of continued use.
- It is also important to note that myo-inositol works best when taken in conjunction with a healthy diet and lifestyle, so be sure to eat a balanced diet, exercise regularly, and manage stress for optimal results.
Potential side effects of myo-inositol powder and Inofolic Soft-Gel Capsules
Inofolic softgel capsules are generally safe and well-tolerated, with no contraindications. It is important to note that supplementation with folic acid can mask a vitamin B12 deficiency. If you are unsure whether you are taking enough vitamin B12, consult a healthcare provider.
Where to buy Inofolic Soft-Gel Capsules in Canada
Inofolic softgel capsules are easily available for purchase in Canada. You can find them online at Amazon, Well.ca, and Pharmexdirect.com. We are also available in pharmacy stores across Canada upon pharmacist request. These trusted retailers ensure that you are getting genuine Inofolic softgel capsules that meet the highest quality standards. Learn more about where to purchase Inofolic softgel capsules here.
References:
- Carlomagno G, De Grazia S, Unfer V, Manna F. Myo-inositol in a new pharmaceutical form: a step forward to a broader clinical use. Expert Opin Drug Deliv. 2012 Mar;9(3):267-71. doi: 10.1517/17425247.2012.662953. PMID: 22339497.
- Damian, F.; Harati, M.; Schwartzenhauer, J.; Van Cauwenberghe, O.;Wettig, S.D. Challenges of Dissolution Methods Development for Soft Gelatin Capsules. Pharmaceutics 2021, 13, 214. https://doi.org/10.3390/ pharmaceutics13020214
